Our proprietary Transient Permeability Enhancer, or TPE®, technology, developed internally by our scientists, is designed to enable the development of oral forms of medications that are currently only available as injections.

How TPE® Works

Billions of dollars are spent each year on approved injectable peptide and small molecule drugs, with numerous additional agents in clinical development. The parenteral route of administration has generally been chosen because these agents are degraded by digestive enzymes and are then blocked by the transcellular and paracellular routes within the epithelium, resulting in sub-therapeutic bioavailability and response.

TPE aims to protect drug molecules from digestive enzymes and to trigger the temporary expansion of tight junctions between cells of the intestinal epithelium, a naturally occurring process. As a result, drug molecules may pass into the blood stream while larger structures such as toxins, bacteria and viruses are excluded.

TPE’s ability to enhance oral bioavailability is the result of a combination of excipients that create a lipophilic suspension of solid hydrophilic particles in a hydrophobic medium.

In all chronic toxicology and clinical trials, there have been no TPE-related safety signals or formulation-related adverse events. The adverse events that have been detected were associated with side effects of the study drug itself and the underlying disease.


  • Melmed S, al. “Safety and Efficacy of Oral Octreotide in Acromegaly: Results of a Multicenter Phase III Trial.” The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 4, 1 April 2015, Pages 1699–1708, https://doi.org/10.1210/jc.2014-4113
  • Tuvia S, et. Al. “A Novel Suspension Formulation Enhances Intestinal Absorption of Macromolecules Via Transient and Reversible Transport Mechanisms.” Pharmaceutical Research, Volume 31, issue 8, 21 February 2014, Pages 2010–2021, https://doi.org/10.1007/s11095-014-1303-9


Drug candidates developed using our Transient Permeability Enhancer (TPE®) technology are investigational and have not been approved by the U.S. Food and Drug Administration, the European Medicines Agency, or any other regulatory agency.